This is the 7614th most frequent Spanish word.
kike
The word "kike" is not Spanish; it's an offensive English slur used against Jewish people.
Here, 'Kike' is used as a diminutive nickname, commonly for names like Enrique.
Kike es mi amigo desde la infancia.
Kike is my friend from childhood.
Again, 'Kike' is a proper noun referring to a person's nickname or informal name.
A Kike le gusta jugar fútbol todos los días.
Kike likes to play soccer every day.
In this case, 'kike' refers to its usage as a term that can be interpreted as a slur in English, and it is being explained contextually.