This is the 5201st most frequent Polish word.
pytaniami
"Pytaniami" means "questions" in the instrumental plural form in Polish.
Here, 'pytaniami' means 'questions' in the instrumental case, plural, showing the tool or means of action.
On zasypuje mnie pytaniami dotyczącymi projektu.
He bombards me with questions about the project.
In this sentence, 'pytaniami' again is in the instrumental case, emphasizing the means of annoyance.
Niech mnie więcej nikt nie dręczy pytaniami na ten temat.
Let no one bother me further with questions on this topic.
Here, 'pytania' is in a different form, nominative plural, as part of the object in the conversation.