This is the 4526th most frequent Turkish word.
ağrısıyla
"With its pain" or "with the pain."
Here 'ağrısıyla' refers to the headache causing difficulty at the start of the day.
Başım ağrısıyla güne zor başladım.
I started the day with difficulty due to my headache.
Here 'ağrısıyla' symbolizes emotional pain or lack of affection felt by the person.
Kalbinde sevgisizlik ağrısıyla yaşamak zorundaydı.
She had to live with the pain of lovelessness in her heart.
In this sentence, 'ağrısıyla' represents the discomfort or pain caused by the wound.