This is the 4164th most frequent Russian word.
семья
"Семья" means "family" in English.
In this sentence, 'семья' refers to the person's family as a whole unit.
Моя семья живет в большом доме.
My family lives in a big house.
Here, 'семья' is in the instrumental case, indicating the people with whom the action is performed.
Я провожу выходные с семьёй.
I spend weekends with my family.
The word 'семья' is associated here as a base root, showing possession or relevance.