This is the 1153rd most frequent Polish word.
sześciu
"Six" (in the masculine personal genitive form).
Here, 'sześciu' is the genitive masculine personal numeral used to describe the number of masculine personal nouns, in this case 'brothers'.
Mam sześciu braci.
I have six brothers.
In this instance, 'sześciu' takes the locative form because it's used in a context following 'o', which requires the locative case.
Porozmawiajmy o sześciu sprawach.
Let's talk about six matters.
Here, 'sześciu' is used in the genitive form because it describes minutes in a context showing lack or deficit, which typically requires the use of the genitive case.