This is the 12546th most frequent Korean word.
대마초에
"대마초에" means "marijuana" or "cannabis" in English.
In this case, '대마초에' indicates the entity associated with the problem, signified by '문제가 생기다.'
대마초에 문제가 생겼어요.
A problem has occurred with marijuana.
In this sentence, '대마초에' is part of a phrase indicating interest or focus towards marijuana, shown by the verb '관심이 많다.'
그는 대마초에 관심이 많아요.
He is very interested in marijuana.
Here, '대마초에' is used with '대해' to mean 'about marijuana,' indicating the topic of the research.