This is the 9813th most frequent Korean word.
고통에는
"고통에는" translates to "in pain" or "regarding pain."
Here, '고통에는' is used to indicate the subject 'pain', with '-는' marking the topic focus.
고통에는 끝이 있다.
Pain has an end.
'고통에는' focuses on the concept of pain as a topic, suggesting reasons might exist for it.
고통에는 이유가 있을지도 모른다.
There might be a reason for pain.
In this context, '고통에는' is used to highlight that pain has qualities intrinsic to life.