This is the 8582nd most frequent Japanese word.
掴め
"掴め" means "grasp it" or "grab it."
In this usage, '掴め' indicates understanding or comprehending an abstract concept, such as the meaning of someone's story.
彼の話の意味が掴めない。
I cannot grasp the meaning of his story.
In this context, '掴め' refers to physically holding or grasping an object firmly with one's hand.
ボールをしっかり掴め。
Hold the ball tightly.
Here, '掴め' is used as an imperative verb form meaning 'seize' or 'grab'. It is employed to emphasize taking action actively.