This is the 9231st most frequent Japanese word.
生ず
"生ず" (しょうず) means "to occur" or "to arise."
In this sentence, '生ずる' (shōzuru) translates to 'arise' or 'occur,' used to describe the emergence or happening of issues.
自然環境の保護が怠ると、多くの問題が生ずる可能性がある。
If the preservation of the natural environment is neglected, many problems may arise.
Here, '生じる' (shōjiru), a variation of '生ず', refers to the arising or developing of internal states like anxiety.
心の中に不安が生じる時、人はその原因を探ろうとする。
When anxiety arises in one's mind, people tend to explore its cause.
In this case, '生じさせる' is a causative form of '生ず', meaning to cause or bring about something.