This is the 9098th most frequent Japanese word.
潰せ
"潰せ" means "crush it" or "destroy it."
潰す in this context means to eliminate or reduce something.
ジョギングはストレスを潰せます。
Jogging can alleviate stress.
潰す here refers to physically tearing down or shuttering something, such as a building or facility.
その工場は潰せない状況です。
The factory cannot be destroyed in this situation.
潰す in this example is used to while away time or spend it doing something enjoyable or engaging.